ABSTRACT
The histopathological and ultrastructural changes of the lungs of 11 pigs suffering from comminuted fracture of the femur produced by high-velocity sieel bullet were studied. The steel bullet was 7.62 mm in diameter and 1.03 g in weight. The pulmonary changes were observed 24, 48, and 72 hours after injury.It was found that microvascular congestion, aggregation of RBC and WBC, and degranulation of WBC were prominent features 24 hours after injury. The basement membrane of the endothelium was broken. Type I pneumocytes became swollen and deteriorated. The lamellar bodies of Type II pneumocytes were evacuated rapidly. 48 to 72 hours after injury, these pathological changes gradually ameliorated.The pulmonary pathology occurring after bullet - induced fracture observed in this study is similar to that of adult respiratory distress syndrome(ARDS) in character but much milder in intensity. Its prognosis is always fine. Most of the experimental animals showed no symptoms or signs of ARDS. It is concluded that severe limb trauma can induce subclinical ARDS.
ABSTRACT
The pathological changes of the lungs in 16 dogs with blulet-caused fracture of the hind legs were studied. Under light microscopy, the pathological features were marked capillary congestion, extravasation of red cells in either the interstitium or alveolar spaces, atelectasis, leucocyte infiltration of the interstitium, mild pulmonary edema, and fat emboli in the small vessels. These changes, with the exception of fat embolism, were found to occur 2 hours after injury, and were fully developed around 24 hours. Then fat embolism supervened. Most of the changes gradually subsided and disappeared as time went by.The results of this study indicate that there can be pathological lesions in the lungs secondary to the bullet-induced fracture of the hind legs in dogs.
ABSTRACT
The separation,purification and activity determination of basic fibroblast growth factor (bFGF) with nucleic acid molecular hybridization was described and the changes of bFGF in lung injury treated with prostacy-clin were observed.It was found that bioactive bFGF and bFGF-mRNA could only be found in the injured lung tissues but not in the normal lungs.Administration of prostacyclin could slightly elevate the activity of bFGF and signficantly increase the level of bFGF-mRNA.The findings of this study suggest that there is an increase of bFGF level after lung injury,prostacyclin can influence the expression of bFGF,and bFGF plays an important role in the repair of the injured lung tissues.